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Article

Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer.

Virchows Archiv : an international journal of pathology - 1 Feb 2002

Sato Kiyoshi, Tamura Gen, Tsuchiya Takashi, Endoh Yasushi, Sakata Ken, Motoyama Teiichi, Usuba Osamu, Kimura Wataru, Terashima Masanori, Nishizuka Satoshi, Zou Tongtong, Meltzer Stephen J

Abstract excerpt

The PTEN tumor suppressor gene on 10q23.3, responsible for the Cowden and Bannayan-Zonana syndromes, encodes a dual-specificity phosphatase able to dephosphorylate both tyrosine phosphate and serine/threonine phosphate residues. Mutational inactivation of PTEN has been reported in various maligna...

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Share to DNA, Neoplasm
Share to Gene Silencing
Share to Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Single-Stranded Conformational

Share to PTEN Phosphohydrolase

Share to Stomach Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 11964046
DOI: 10.1007/s004280100499

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11964046-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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