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Article

Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer.

Virchows Archiv : an international journal of pathology - 1 Feb 2002

Sato Kiyoshi, Tamura Gen, Tsuchiya Takashi, Endoh Yasushi, Sakata Ken, Motoyama Teiichi, Usuba Osamu, Kimura Wataru, Terashima Masanori, Nishizuka Satoshi, Zou Tongtong, Meltzer Stephen J

Abstract excerpt

The PTEN tumor suppressor gene on 10q23.3, responsible for the Cowden and Bannayan-Zonana syndromes, encodes a dual-specificity phosphatase able to dephosphorylate both tyrosine phosphate and serine/threonine phosphate residues. Mutational inactivation of PTEN has been reported in various malignancies, including endometrial cancers, ovarian cancers, and glioblastomas. In this study, we investigated PTEN gene...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 11964046
DOI: 10.1007/s004280100499

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer.PMID 11964046Read ↗

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