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Article

Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer.

Journal of the National Cancer Institute - 5 Feb 2003

Izzo Julie G, Papadimitrakopoulou Vassiliki A, Liu Diane D, den Hollander Petra L C, Babenko Ilona M, Keck Jamie, El-Naggar Adel K, Shin Dong M, Lee J Jack, Hong Waun K, Hittelman Walter N

Abstract excerpt

BACKGROUND: Altered cyclin D1 expression in advanced preinvasive lesions of the upper aerodigestive tract (UADT) is associated with an increased risk of developing cancer and histologic progression during and after combination biochemopreventive therapy (13-cis-retinoic acid, alpha-interferon, and alpha-tocopherol). Both alleles of the adenine (A)/guanine (G) cyclin D1 polymorphism located at nucleotide 870...

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PMID: 12569141
DOI: 10.1093/jnci/95.3.198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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