Article
Biologic correlates of a biochemoprevention trial in advanced upper aerodigestive tract premalignant lesions.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2002
Papadimitrakopoulou Vassiliki A, Liu Diane D, Mao Li, Shin Dong M, El-Naggar Adel, Ibarguen Heladio, Lee J Jack, Hong Waun K, Hittelman Walter N
Abstract excerpt
OBJECTIVE: To identify tissue biomarkers that might be used to assess an individual's cancer risk and response to chemoprevention, we studied in dysplastic lesions of the larynx and the p.o. cavity, a series of biomarkers extensively used in previous chemoprevention trials, including chromosome polysomy (CP), proliferative status, p53 expression and gene mutations, and loss of heterozygosity at 9p, 3p, and 17p....
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