Article
Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy.
Journal of the National Cancer Institute - 21 Oct 1998
Mao L, El-Naggar A K, Papadimitrakopoulou V, Shin D M, Shin H C, Fan Y, Zhou X, Clayman G, Lee J J, Lee J S, Hittelman W N, Lippman S M, Hong W K
Abstract excerpt
BACKGROUND: The goal of chemoprevention is to reduce the risk of cancer development by reversing or blocking the tumorigenic process through the use of pharmacologic or natural agents. To determine the potential role of genetic alterations in assessing cancer risk and in evaluating the efficacy o...
Topics
- Antineoplastic Agents
- Chromosomes, Human, Pair 9
- DNA, Neoplasm
- Female
- Genotype
- Head and Neck Neoplasms
- Humans
- Interferon-alpha
- Isotretinoin
- Loss of Heterozygosity
- Male
- Microsatellite Repeats
- Phenotype
- Polymerase Chain Reaction