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Article

Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy.

Journal of the National Cancer Institute - 21 Oct 1998

Mao L, El-Naggar A K, Papadimitrakopoulou V, Shin D M, Shin H C, Fan Y, Zhou X, Clayman G, Lee J J, Lee J S, Hittelman W N, Lippman S M, Hong W K

Abstract excerpt

BACKGROUND: The goal of chemoprevention is to reduce the risk of cancer development by reversing or blocking the tumorigenic process through the use of pharmacologic or natural agents. To determine the potential role of genetic alterations in assessing cancer risk and in evaluating the efficacy of chemopreventive agents, we studied 22 patients with advanced premalignant lesions of the head and neck who were part...

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PMID: 9790547
DOI: 10.1093/jnci/90.20.1545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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