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Article

Polymorphism ratio sequencing: a new approach for single nucleotide polymorphism discovery and genotyping.

Genome research - 1 Feb 2003

Blazej Robert G, Paegel Brian M, Mathies Richard A

Abstract excerpt

Polymorphism ratio sequencing (PRS) combines the advantages of high-throughput DNA sequencing with new labeling and pooling schemes to produce a powerful assay for sensitive single nucleotide polymorphism (SNP) discovery, rapid genotyping, and accurate, multiplexed allele frequency determination. In the PRS method, dideoxy-terminator extension ladders generated from a sample and reference template are labeled...

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Identifiers

PMID: 12566407
DOI: 10.1101/gr.396203
PMCID: PMC420372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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