High-throughput single-nucleotide polymorphism genotyping by fluorescent competitive allele-specific polymerase chain reaction (SNiPTag).

doi:10.1006/abio.2001.5509

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Article

High-throughput single-nucleotide polymorphism genotyping by fluorescent competitive allele-specific polymerase chain reaction (SNiPTag).

Analytical biochemistry - 15 Feb 2002

McClay Joseph L, Sugden Karen, Koch Helga G, Higuchi Susumi, Craig Ian W

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are becoming widely recognized as the new currency for gene mapping as increasing numbers are discovered. Here we outline a method for their rapid analysis based on an allele-specific polymerase chain reaction (PCR) which employs a competitive approach, whereby both allele-specific primers are present in the same reaction and carry different fluorescent labels. This...

Topics

Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Alleles
DNA Primers
Fluorescent Dyes
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Staining and Labeling

Source

Open in PubMed

Identifiers

PMID: 11814290
DOI: 10.1006/abio.2001.5509

Genes

ALDH2

Provenance

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