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Article

Transcriptional activation of the utrophin promoter B by a constitutively active Ets-transcription factor.

Neuromuscular disorders : NMD - 1 Feb 2003

Briguet Alexandre, Bleckmann Dorothee, Bettan Mickaël, Mermod Nicolas, Meier Thomas

Abstract excerpt

Duchenne muscular dystrophy is an X-linked genetic disease caused by the absence of functional dystrophin. Pharmacological upregulation of utrophin, the autosomal homologue of dystrophin, offers a potential therapeutic approach to treat Duchenne patients. Full-length utrophin mRNA is transcribed from two alternative promoters, called A and B. In contrast to the utrophin promoter A, little is known about the...

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PMID: 12565912
DOI: 10.1016/s0960-8966(02)00217-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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