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Article

The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine.

The journal of gene medicine - 1 Feb 2005

Takahashi Joji, Itoh Yuka, Fujimori Keita, Imamura Michihiro, Wakayama Yoshihiro, Miyagoe-Suzuki Yuko, Takeda Shin'ichi

Abstract excerpt

BACKGROUND: Duchenne muscular dystrophy (DMD) is caused by the absence of the muscle cytoskeletal protein dystrophin. Utrophin is an autosomal homologue of dystrophin, and overexpression of the protein is expected to compensate for the defect of dystrophin. The utrophin gene has two promoters, A and B, and promoter A of the utrophin gene is a possible target of pharmacological interventions for DMD because...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15538725
DOI: 10.1002/jgm.651

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine.PMID 15538725Read ↗

A- and B-utrophin Have Different Expression Patterns and Are Differentially Up-regulated in mdx MuscleSemantic proximity Read ↗

Transcriptional activation of the utrophin promoter B by a constitutively active Ets-transcription factor.Semantic proximity Read ↗

Local transcriptional control of utrophin expression at the neuromuscular synapse.Semantic proximity Read ↗

Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.Semantic proximity Read ↗

Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice.Semantic proximity Read ↗

Heregulin ameliorates the dystrophic phenotype in mdx mice.Semantic proximity Read ↗

A Cell-Based High-Throughput Screening Assay for Posttranscriptional Utrophin UpregulationSemantic proximity Read ↗

The utrophin and dystrophin genes share similarities in genomic structureSemantic proximity Read ↗

Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeuticsSemantic proximity Read ↗

Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophinSemantic proximity Read ↗

Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice.Semantic proximity Read ↗

Induction of utrophin gene expression by heregulin in skeletal muscle cells: Role of the N-box motif and GA binding proteinSemantic proximity Read ↗

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