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Article

Heregulin ameliorates the dystrophic phenotype in mdx mice.

Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2004

Krag Thomas O B, Bogdanovich Sasha, Jensen Claus J, Fischer M Dominik, Hansen-Schwartz Jacob, Javazon Elisabeth H, Flake Alan W, Edvinsson Lars, Khurana Tejvir S

Abstract excerpt

Duchenne's muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional motifs with dystrophin. Utrophin's ability to compensate for dystrophin during development and when transgenically overexpressed has provided an important impetus for identifying activators of utrophin expression. The utrophin...

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Share to DMD gene
Share to Injections, Intraperitoneal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred mdx

Share to Muscular Dystrophy, Animal

Share to Neuregulin-1

Share to Phenotype

Share to Utrophin

Source

Open in PubMed Open full text

Identifiers

PMID: 15365169
DOI: 10.1073/pnas.0405972101
PMCID: PMC518764

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Heregulin ameliorates the dystrophic phenotype in mdx mice.PMID 15365169Read ↗

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Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice.Semantic proximity Read ↗

Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx miceSemantic proximity Read ↗

Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.Semantic proximity Read ↗

Functional Substitution by TAT-Utrophin in Dystrophin-Deficient MiceSemantic proximity Read ↗

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophySemantic proximity Read ↗

Daily Treatment with SMTC1100, a Novel Small Molecule Utrophin Upregulator, Dramatically Reduces the Dystrophic Symptoms in the mdx MouseSemantic proximity Read ↗

A- and B-utrophin Have Different Expression Patterns and Are Differentially Up-regulated in mdx MuscleSemantic proximity Read ↗

Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation.Semantic proximity Read ↗

Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic musclesSemantic proximity Read ↗

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