Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of utrophin gene expression by heregulin in skeletal muscle cells: Role of the N-box motif and GA binding protein

16 Mar 1999

Abstract excerpt

The modulation of utrophin gene expression in muscle by the nerve-derived factor agrin plausibly involves the trophic factor ARIA/heregulin. Here we show that heregulin treatment of mouse and human cultured myotubes caused a approximately 2.5-fold increase in utrophin mRNA levels. Transient transfection experiments with utrophin promoter-reporter gene constructs showed that this increase resulted from an enhanced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exercise and Physiological Responses
Share to Muscle Physiology and Disorders
Share to Neurobiology and Insect Physiology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10077665
DOI: 10.1073/pnas.96.6.3223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of utrophin gene expression by heregulin in skeletal muscle cells: Role of the N-box motif and GA binding proteinPMID 10077665Read ↗

Heregulin ameliorates the dystrophic phenotype in mdx mice.Semantic proximity Read ↗

The Ets transcription factor GABP is required for postsynaptic differentiation in vivo.Semantic proximity Read ↗

Transcriptional activation of the utrophin promoter B by a constitutively active Ets-transcription factor.Semantic proximity Read ↗

Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.Semantic proximity Read ↗

Targeting of the ETS factor GABPalpha disrupts neuromuscular junction synaptic function.Semantic proximity Read ↗

Local transcriptional control of utrophin expression at the neuromuscular synapse.Semantic proximity Read ↗

The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine.Semantic proximity Read ↗

A- and B-utrophin Have Different Expression Patterns and Are Differentially Up-regulated in mdx MuscleSemantic proximity Read ↗

Loss of sarcospan exacerbates pathology in mdx mice, but does not affect utrophin amelioration of disease.Semantic proximity Read ↗

Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx miceSemantic proximity Read ↗

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONSSemantic proximity Read ↗

Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic musclesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.