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Article

Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice

26 May 2009

Abstract excerpt

BACKGROUND: The loss of dystrophin compromises muscle cell membrane stability and causes Duchenne muscular dystrophy and/or various forms of cardiomyopathy. Increased expression of the dystrophin homolog utrophin by gene delivery or pharmacologic up-regulation has been demonstrated to restore membrane integrity and improve the phenotype in the dystrophin-deficient mdx mouse. However, the lack of a viable therapy...

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PMID: 19478831
DOI: 10.1371/journal.pmed.1000083

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Functional Substitution by TAT-Utrophin in Dystrophin-Deficient MicePMID 19478831Read ↗

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