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Article

Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas.

Biochemical and biophysical research communications - 7 Feb 2003

Wakabayashi Yuichi, Inoue Jun, Takahashi Yoshiaki, Matsuki Atsushi, Kosugi-Okano Hitomi, Shinbo Toshimitsu, Mishima Yukio, Niwa Ohtsura, Kominami Ryo

Abstract excerpt

Allelic loss (LOH) mapping and sequence analysis were conducted for gamma-ray induced mouse thymic lymphomas and a novel tumor suppressor gene, Rit1/Bcl11b, on chromosome 12 was isolated. Bi-allelic changes were found in 17 of the 66 p53-proficient lymphomas with Rit1 LOH but in only 2 of the 54 p53-deficient lymphomas. This suggests an association between the presence of functional p53 and inactivation of the...

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PMID: 12565905
DOI: 10.1016/s0006-291x(02)03069-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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