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Article

[Aminoglycoside ototoxicity associated with mitochondrial DNA mutation].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology - 1 May 1999

Ke X, Qi Y, Gu Z, Zhang Z, Zhang W, Jiang S, Liu J

Abstract excerpt

OBJECTIVE: To confirm the effect of genetic susceptibility to aminoglycoside ototoxicity. METHOD: Mitochondrial DNA (mtDNA) from 62 members of 9 aminoglycoside induced deafness families was analysed by PCR-Restriction endonuclease digestion. RESULT: The nucleotide 1555A-->G mutation in 12S rRNA gene of mtDNA was identified in 20 members of 5 families. CONCLUSION: These findings indicate that this mutation is a...

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PMID: 12563999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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