[Prevalence of the A1555G mutation in the mitochondrial DNA in patients with cochlear or vestibular damage due to aminoglycoside-induced ototoxicity].

doi:10.1016/s0001-6519(04)78511-8

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Article

[Prevalence of the A1555G mutation in the mitochondrial DNA in patients with cochlear or vestibular damage due to aminoglycoside-induced ototoxicity].

Acta otorrinolaringologica espanola - 1 May 2004

Gallo-Terán J, Arellano B, Morales-Angulo C, Modamio-Høybjør S, Moreno-Pelayo M A, Ramírez-Camacho R, del Castillo I, Moreno F

Abstract excerpt

OBJECTIVE: To determine the frequency of the A1555G mutation in the mitochondrial genome among Spanish patients with aminoglycoside-induced ototoxicity. PATIENTS AND METHODS: We screened 25 unrelated cases, totalling 39 individuals with cochlear or vestibular damage due to aminoglycoside-induced ototoxicity. This group was made up of 18 subjects from 4 unrelated families with a history of aminoglycoside...

Topics

Adolescent
Adult
Aged
Aminoglycosides
DNA, Mitochondrial
Female
Hearing Loss
Humans
Male
Middle Aged
Mutation
Spain

Source

Open in PubMed

Identifiers

PMID: 15461317
DOI: 10.1016/s0001-6519(04)78511-8

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