Article
The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts.
Nucleic acids research - 1 Nov 2000
Gamper H B, Parekh H, Rice M C, Bruner M, Youkey H, Kmiec E B
Abstract excerpt
Chimeric oligonucleotides (chimeras), consisting of RNA and DNA bases folded by complementarity into a double hairpin conformation, have been shown to alter or repair single bases in plant and animal genomes. An uninterrupted stretch of DNA bases within the chimera is known to be active in the se...
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