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Article

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans.

Experimental gerontology - 1 Dec 2002

Houthoofd Koen, Braeckman Bart P, Lenaerts Isabelle, Brys Kristel, De Vreese Annemie, Van Eygen Sylvie, Vanfleteren Jacques R

Abstract excerpt

Culture in axenic medium causes two-fold increases in the length of development and adult life span in Caenorhabditis elegans. We asked whether axenic medium imposes dietary restriction (ADR), and causes changes in metabolic activity and stress resistance. Eat mutants, which have a reduced food intake, were studied in parallel with wild-type worms to assess potential synergistic actions of axenic culture and food...

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PMID: 12559406
DOI: 10.1016/s0531-5565(02)00173-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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