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Article

The two isoforms of the cAMP-dependent protein kinase catalytic subunit are involved in the control of dimorphism in the human fungal pathogen Candida albicans.

Fungal genetics and biology : FG & B - 1 Feb 2003

Cloutier Monikca, Castilla Rocío, Bolduc Nathalie, Zelada Alicia, Martineau Philippe, Bouillon Marlène, Magee Beatrice B, Passeron Susana, Giasson Luc, Cantore María L

Abstract excerpt

We have cloned the Candida albicans TPK2 gene encoding a cAMP-dependent protein kinase (PKA) catalytic subunit and generated a tpk2 homozygous null mutant to assess its ability to germinate in liquid media. N-acetylglucosamine (GlcNAc)-induced germ-tube formation was attenuated in the tpk2 strain and enhanced by compounds that are known to increase the PKA activity in situ. Germination was completely blocked in...

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Source

Identifiers

PMID: 12553943
DOI: 10.1016/s1087-1845(02)00520-0

Genes

TPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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