Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans.

Molecular microbiology - 1 Dec 2001

Bockmühl D P, Krishnamurthy S, Gerads M, Sonneborn A, Ernst J F

Abstract excerpt

TPK1 and TPK2 encode both isoforms of protein kinase A (PKA) catalytic subunits in Candida albicans. Mutants lacking both TPK1 alleles showed defective hyphal morphogenesis on solid inducing media, whereas in liquid hypha, formation was affected slightly. In contrast, tpk2 mutants were only partially morphogenesis defective on solid media, whereas a strong block was observed in liquid. In addition, the yeast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Isoenzymes

Share to Morphogenesis

Share to Peptides

Share to Protein Subunits

Share to Restriction Mapping

Source

Identifiers

PMID: 11886556
DOI: 10.1046/j.1365-2958.2001.02688.x

Genes

TPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans.PMID 11886556Read ↗

Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans.Semantic proximity Read ↗

Protein kinase A governs growth and virulence in Candida tropicalisSemantic proximity Read ↗

Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.Semantic proximity Read ↗

Global regulatory roles of the cAMP/PKA pathway revealed by phenotypic, transcriptomic and phosphoproteomic analyses in a null mutant of the PKA catalytic subunit in Candida albicans.Semantic proximity Read ↗

A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans.Semantic proximity Read ↗

Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit.Semantic proximity Read ↗

The two isoforms of the cAMP-dependent protein kinase catalytic subunit are involved in the control of dimorphism in the human fungal pathogen Candida albicans.Semantic proximity Read ↗

<i>Candida albicans</i> filamentation does not require the cAMP-PKA pathway in vivoSemantic proximity Read ↗

DYRK-family kinases regulate Candida albicans morphogenesis and virulence through the Ras1/PKA pathwaySemantic proximity Read ↗

Regulatory complexity of cellular differentiation in Candida albicans revealed through systematic screening of protein kinase mutants.Semantic proximity Read ↗

Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris.Semantic proximity Read ↗

Multiple roles and diverse regulation of the Ras/cAMP/protein kinase A pathway in Candida albicansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.