Article
Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus.
Applied and environmental microbiology - 1 Aug 2008
Grosse Christina, Heinekamp Thorsten, Kniemeyer Olaf, Gehrke Alexander, Brakhage Axel A
Abstract excerpt
Aspergillus fumigatus is an opportunistic human pathogenic fungus causing severe infections in immunocompromised patients. Cyclic AMP (cAMP) signal transduction plays an important role in virulence. A central component of this signaling cascade is protein kinase A (PKA), which regulates cellular processes by phosphorylation of specific target proteins. Here we describe the generation and analysis of A. fumigatus...
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