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Article

Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus.

Applied and environmental microbiology - 1 Aug 2008

Grosse Christina, Heinekamp Thorsten, Kniemeyer Olaf, Gehrke Alexander, Brakhage Axel A

Abstract excerpt

Aspergillus fumigatus is an opportunistic human pathogenic fungus causing severe infections in immunocompromised patients. Cyclic AMP (cAMP) signal transduction plays an important role in virulence. A central component of this signaling cascade is protein kinase A (PKA), which regulates cellular processes by phosphorylation of specific target proteins. Here we describe the generation and analysis of A. fumigatus...

Topics

Aspergillosis
Aspergillus
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
DNA, Fungal
Fungal Proteins
Humans
Phenotype
Pigments, Biological
Plasmids
Proteome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spores, Fungal

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Identifiers

PMID: 18539819
DOI: 10.1128/AEM.00470-08
PMCID: PMC2519360

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