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Article

Serial infection of diverse host (Mus) genotypes rapidly impedes pathogen fitness and virulence.

Proceedings. Biological sciences - 7 Jan 2015

Kubinak Jason L, Cornwall Douglas H, Hasenkrug Kim J, Adler Frederick R, Potts Wayne K

Abstract excerpt

Reduced genetic variation among hosts may favour the emergence of virulent infectious diseases by enhancing pathogen replication and its associated virulence due to adaptation to a limited set of host genotypes. Here, we test this hypothesis using experimental evolution of a mouse-specific retroviral pathogen, Friend virus (FV) complex. We demonstrate rapid fitness (i.e. viral titre) and virulence increases when...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25392466
DOI: 10.1098/rspb.2014.1568
PMCID: PMC4262163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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