Article
Determination of spontaneous mutation frequencies in measles virus under nonselective conditions.
Journal of virology - 1 Mar 2013
Zhang Xiaomeng, Rennick Linda J, Duprex W Paul, Rima Bert K
Abstract excerpt
There is a paradox between the remarkable genetic stability of measles virus (MV) in the field and the high mutation rates implied by the frequency of the appearance of monoclonal antibody escape mutants generated when the virus is pressured to revert in vitro (S. J. Schrag, P. A. Rota, and W. J. Bellini, J. Virol. 73:51-54, 1999). We established a highly sensitive assay to determine frequencies of various...
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