Article
Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.
The Journal of cell biology - 3 Feb 2003
Babu J Ramesh, Jeganathan Karthik B, Baker Darren J, Wu Xiaosheng, Kang-Decker Ningling, van Deursen Jan M
Abstract excerpt
The WD-repeat proteins Rae1 and Bub3 show extensive sequence homology, indicative of functional similarity. However, previous studies have suggested that Rae1 is involved in the mRNA export pathway and Bub3 in the mitotic checkpoint. To determine the in vivo roles of Rae1 and Bub3 in mammals, we generated knockout mice that have these genes deleted individually or in combination. Here we show that...
Topics
- Active Transport, Cell Nucleus
- Aneuploidy
- Animals
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chromosomal Proteins, Non-Histone
- Chromosome Aberrations
- Chromosome Segregation
- Female