Article
[Construction of chimeric tumor suppressor p53 resistant to the dominant-negative interaction with p53 mutants].
Molekuliarnaia biologiia - 1 Jan 2000
Almazov V P, Morgunkova A A, Kalinin V N, Kopnin B P, Prasolov V S, Chumakov P M
Abstract excerpt
A chimeric p53 cDNA was constructed so that the fragment coding for 39 residues of the chicken p53 tetramerization domain replaced the corresponding region of human p53. The chimeric cDNA substantially inhibited the colony-forming ability of transfected human and mouse cells, suggesting a suppressory potential for its product. The chimeric p53 activated promoters containing p53-responsive elements. In contrast to...
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