[Isolation and applications of transformation suppressor genes].

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Article

[Isolation and applications of transformation suppressor genes].

Nihon rinsho. Japanese journal of clinical medicine - 1 Aug 2015

Noda Makoto, Matsuzaki Tomoko, Yoshida Yoko, Kitayama Hitoshi

Abstract excerpt

A common strategy to identify tumor suppressor genes has been positional cloning, taking advantages of chromosomal abnormalities, linkage to polymorphic markers, etc. We have been taking another approach, based on shotgun cloning with cDNA-expression library, to isolate genes suppressing an aspect of transformed phenotypes. Genes identified in such an artificial system, however, require subsequent validation for...

Topics

Animals
Antigens, Neoplasm
Biomarkers, Tumor
Cell Transformation, Neoplastic
Cloning, Molecular
Drug Discovery
GPI-Linked Proteins
Gene Library
Genes, Tumor Suppressor
Humans
Lectins, C-Type
Mice
Mutation
Neoplasms
Pancreatitis-Associated Proteins

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PMID: 26281680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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