Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

15 Aug 2011

Abstract excerpt

Multiple human epidemiologic studies link caffeinated (but not decaffeinated) beverage intake with significant decreases in several types of cancer, including highly prevalent UV-associated skin carcinomas. The mechanism by which caffeine protects against skin cancer is unknown. Ataxia telangiectasia and Rad3-related (ATR) is a replication checkpoint kinase activated by DNA stresses and is one of several targets...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21844338
DOI: 10.1073/pnas.1111378108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinasePMID 21844338Read ↗

ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of CaffeineSemantic proximity Read ↗

Green tea prevents non-melanoma skin cancer by enhancing DNA repairSemantic proximity Read ↗

ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cellsSemantic proximity Read ↗

Photodynamic Therapy and Dietary Antioxidants: A Dual Strategy for Genome Stability and DNA Damage RepairSemantic proximity Read ↗

Epigenetic Alterations in Ultraviolet Radiation‐Induced Skin Carcinogenesis: Interaction of Bioactive Dietary Components on Epigenetic Targets<sup>†</sup>Semantic proximity Read ↗

Roles of Chk2 / CHEK2 in guarding against environmentally induced DNA damage and replication‐stressSemantic proximity Read ↗

Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum CSemantic proximity Read ↗

Proanthocyanidins Inhibit Photocarcinogenesis through Enhancement of DNA Repair and Xeroderma Pigmentosum Group A–Dependent MechanismSemantic proximity Read ↗

Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice.Semantic proximity Read ↗

FANCD2 limits acetaldehyde‐induced genomic instability during DNA replication in esophageal keratinocytesSemantic proximity Read ↗

Mechanisms and implications of the age‐associated decrease in DNA repair capacitySemantic proximity Read ↗

Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.