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Article

Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor.

The Journal of biological chemistry - 12 Oct 2007

Rendon Beatriz E, Roger Thierry, Teneng Ivo, Zhao Ming, Al-Abed Yousef, Calandra Thierry, Mitchell Robert A

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is expressed and secreted in response to mitogens and integrin-dependent cell adhesion. Once released, autocrine MIF promotes the activation of RhoA GTPase leading to cell cycle progression in rodent fibroblasts. We now report that small interfering RNA-mediated knockdown of MIF and MIF small molecule antagonism results in a greater than 90% loss of both the migratory...

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Identifiers

PMID: 17709373
DOI: 10.1074/jbc.M704898200

Genes

MIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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