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Article

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Fingerle-Rowson G, Petrenko O, Metz C N, Forsthuber T G, Mitchell R, Huss R, Moll U, Müller W, Bucala R

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is a mediator of host immunity and functions as a high, upstream activator of cells within the innate and the adaptive immunological systems. Recent studies have suggested a potentially broader role for MIF in growth regulation because of its ability to antagonize p53-mediated gene activation and apoptosis. To better understand MIF's activity in growth control, we...

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Identifiers

PMID: 12878730
DOI: 10.1073/pnas.1533295100
PMCID: PMC170922

Genes

MIF

Provenance

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The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.PMID 12878730Read ↗

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A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.Semantic proximity Read ↗

Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction.Semantic proximity Read ↗

IFN regulatory factor–8 expression in macrophages governs an antimetastatic programSemantic proximity Read ↗

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Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular sourceSemantic proximity Read ↗

Critical role of cysteine residue 81 of macrophage migration inhibitory factor (MIF) in MIF-induced inhibition of p53 activity.Semantic proximity Read ↗

MIF family members cooperatively inhibit p53 expression and activity.Semantic proximity Read ↗

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration.Semantic proximity Read ↗

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