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Article

Divergent Nitric Oxide Bioavailability in Men and Women With Sickle Cell Disease

21 Jan 2003

Abstract excerpt

BACKGROUND: Although reduced endothelial nitric oxide (NO) bioavailability has been demonstrated in arteriosclerotic vascular disease, the integrity of this system in sickle cell disease remains uncertain. METHODS AND RESULTS: We measured forearm blood flow in 21 patients with sickle cell disease (hemoglobin SS genotype) and 18 black control subjects before and after intra-arterial infusions of acetylcholine,...

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PMID: 12538427
DOI: 10.1161/01.cir.0000044943.12533.a8

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