Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sickle Cell Vasoocclusion: Heterotypic, Multicellular Aggregations Driven by Leukocyte Adhesion

1 Jan 2004

Abstract excerpt

Homozygous expression of sickle beta-globin alters the function of blood cells and the endothelium, producing a wide spectrum of clinical manifestations. Intravital microscopy studies in sickle cell mice suggest that vasoocclusion is a complex, sequential, multistep phenomenon involving (1) endothelial activation by sickle erythrocyte (SSRBC), (2) leukocyte (WBC) adhesion to the endothelium, and (3) the direct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobinopathies and Related Disorders
Share to Iron Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15280090
DOI: 10.1080/10739680490278556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sickle Cell Vasoocclusion: Heterotypic, Multicellular Aggregations Driven by Leukocyte AdhesionPMID 15280090Read ↗

Sickle Red Cell–Endothelium InteractionsSemantic proximity Read ↗

Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell DiseaseSemantic proximity Read ↗

Newer Aspects of the Pathophysiology of Sickle Cell Disease Vaso-OcclusionSemantic proximity Read ↗

The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy.Semantic proximity Read ↗

Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice.Semantic proximity Read ↗

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.Semantic proximity Read ↗

Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell diseaseSemantic proximity Read ↗

The endothelial biology of sickle cell diseaseSemantic proximity Read ↗

New insights into the pathophysiology and development of novel therapies for sickle cell diseaseSemantic proximity Read ↗

<i>In Vivo</i> Studies of Sickle Red Blood CellsSemantic proximity Read ↗

Influence of Hemoglobin Variants on Vaso-Occlusive Phenomena in Sickle Cell Anemia: A ReviewSemantic proximity Read ↗

Circulating activated endothelial cells in sickle cell anemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.