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Article

Sickle Red Cell–Endothelium Interactions

20 Aug 2008

Abstract excerpt

Periodic recurrence of painful vaso-occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle red cell-endothelium interaction has been implicated as a potential initiating mechanism in vaso-occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss in vitro and...

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PMID: 18720225
DOI: 10.1080/10739680802279394

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