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Article

A mathematical model predicting the frequency of aberrant rearrangements in the T-cell receptor gene.

Bio Systems - 1 Dec 1999

Brooks E G

Abstract excerpt

The T-cell receptor (TCR) genetic loci undergo an orderly process of recombination in ontogeny in order to generate a diverse array of antigen receptors. Normally occurring, out-of-frame and incomplete rearrangements produce non-productive TCR transcripts. Abnormalities in the rearrangement process occur at very low frequencies but may predominate in inborn errors of recombination. Detecting these abnormalities...

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PMID: 10658835
DOI: 10.1016/s0303-2647(99)00055-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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