Article
Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.
Developmental cell - 16 Mar 2010
Takayama Yuko, Mamnun Yasmine M, Trickey Michelle, Dhut Susheela, Masuda Fumie, Yamano Hiroyuki, Toda Takashi, Saitoh Shigeaki
Abstract excerpt
Schizosaccharomyces pombe GATA factor Ams2 is responsible for cell cycle-dependent transcriptional activation of all the core histone genes peaking at G1/S phase. Intriguingly, its own protein level also fluctuates concurrently. Here, we show that Ams2 is ubiquitylated and degraded through the SCF (Skp1-Cdc53/Cullin-1-F-box) ubiquitin ligase, in which F box protein Pof3 binds this protein. Ams2 is phosphorylated...
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