Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.

doi:10.1128/MCB.15.10.5531

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Article

Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.

Molecular and cellular biology - 1 Oct 1995

Cortez D, Kadlec L, Pendergast A M

Abstract excerpt

BCR-ABL is a deregulated tyrosine kinase expressed in Philadelphia chromosome-positive human leukemias. Prolongation of hematopoietic cell survival by inhibition of apoptosis has been proposed to be an integral component of BCR-ABL-induced chronic myelogenous leukemia. BCR-ABL elicits transformation of both fibroblast and hematopoietic cells and blocks apoptosis following cytokine deprivation in various...

Topics

Adaptor Proteins, Signal Transducing
Animals
Apoptosis
B-Lymphocytes
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Erythroid Precursor Cells
Fusion Proteins, bcr-abl
GRB2 Adaptor Protein
Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Mice, Nude

Molecular Sequence Data

Mutation

Oncogene Protein p21(ras)

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 7565705
DOI: 10.1128/MCB.15.10.5531
PMCID: PMC230804

Genes

BCR
GRB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7565705-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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