Article
[Pathogenesis of systemic lupus erythematosus].
Zeitschrift fur Rheumatologie - 1 Apr 2015
Alexander T, Radbruch A, Hiepe F
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease with an extremely complex pathogenesis. Due to a genetic predisposition the disease can be induced by multiple stress factors involving epigenetic mechanisms and under the influence of the innate immune system. Defective clearance of immune complexes and apoptotic material together with enhanced neutrophil extracellular trap formation (NETosis) as well...
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