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Article

[Pathogenesis of systemic lupus erythematosus].

Zeitschrift fur Rheumatologie - 1 Apr 2015

Alexander T, Radbruch A, Hiepe F

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease with an extremely complex pathogenesis. Due to a genetic predisposition the disease can be induced by multiple stress factors involving epigenetic mechanisms and under the influence of the innate immune system. Defective clearance of immune complexes and apoptotic material together with enhanced neutrophil extracellular trap formation (NETosis) as well...

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Identifiers

PMID: 25854151
DOI: 10.1007/s00393-014-1456-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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