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Article

Regulatory and pathogenetic mechanisms of autoantibodies in SLE

14 Jan 2011

Abstract excerpt

In the 53 years since the discovery of anti-DNA autoantibodies in lupus [1, 2, 3] , recalcitrant questions have been pondered and possible answers have been debated. The discovery of anti-DNA autoantibodies presented many puzzles: How is immunological tolerance to native B-form DNA broken? What elicits characteristic systemic lupus erythematosus (SLE) autoantibodies? Which of the diverse anti-nuclear reactivities...

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PMID: 21231891
DOI: 10.3109/08916934.2010.536794

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