Article
[Study of deletion and mutation of p16 gene in primary hepatocellular carcinoma].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao - 1 Dec 2001
Qin Y, Chen J, Li B, Sun Z, Zuo F, Sun Z
Abstract excerpt
OBJECTIVE: To investigate the role the deletion and mutation of p16 gene plays in the pathogenesis of human primary hepatocarcinoma. METHODS: Thirty-one cases of human hepatocarcinoma, 31 cases of adjacent noncancerous liver cirrhosis and the leukocytes of 8 normal human subjects were analyzed for deletion and mutation in p16 gene exons 1, 2 and introns 1, 2 with comparative multiple PCR and PCR-SSCP. RESULTS:...
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