[Mutations of several tumor suppressor genes in primary retinoblastoma].

Abstract excerpt

OBJECTIVE: To study the status of several tumor suppressor genes in primary retinoblastoma. METHODS: Single stranded conformation polymorphism (SSCP) analysis associated with direct DNA sequencing was used to identify point mutations in the coding sequence of Rb, p53, p16, p15 and p21 tumor suppressor genes, and multiplex PCR was used to detect big deletion in p16 and p15 genes. RESULTS: Rb gene point mutation...

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