Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants.

Endocrinology - 1 Oct 2003

D'Alessio A, Califano D, Incoronato M, Santelli G, Florio T, Schettini G, Carlomagno M S, Cerchia L, de Franciscis V

Abstract excerpt

The Src homology 2-containing tyrosine phosphatase, Shp-2, is a crucial enzyme that mediates intracellular signaling and is implicated in cell proliferation and differentiation. Here we investigated the involvement of the Shp-2 tyrosine phosphatase in determining the downstream signaling pathways initiated by the Ret oncogene, carrying either the cysteine 634 to tyrosine or the methionine 918 to threonine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glial Cell Line-Derived Neurotrophic Factor
Share to Intracellular Membranes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Growth Factors

Share to Oncogene Proteins

Share to PC12 Cells

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Protein Tyrosine Phosphatases

Share to Proto-Oncogene Proteins c-ret

Source

Identifiers

PMID: 12959980
DOI: 10.1210/en.2003-0620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants.PMID 12959980Read ↗

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes.Semantic proximity Read ↗

Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.Semantic proximity Read ↗

SHP-2 and myeloid malignancies.Semantic proximity Read ↗

Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.Semantic proximity Read ↗

Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors.Semantic proximity Read ↗

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.Semantic proximity Read ↗

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.Semantic proximity Read ↗

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.Semantic proximity Read ↗

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.Semantic proximity Read ↗

Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.Semantic proximity Read ↗

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.