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Article

Basal transcriptional regulation of human damage-specific DNA-binding protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements.

Nucleic acids research - 15 Jan 2003

Nichols Anne F, Itoh Toshiki, Zolezzi Francesca, Hutsell Stephanie, Linn Stuart

Abstract excerpt

The human DDB1 and DDB2 genes encode the 127 and 48 kDa subunits, respectively, of the damage-specific DNA-binding protein (DDB). Mutations in the DDB2 gene have been correlated with the hereditary disease xeroderma pigmentosum group E. We have investigated the proximal promoters of the DDB genes, both of which are G/C-rich and do not contain a TATA box. Transient expression analysis in HeLa cells using a...

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Identifiers

PMID: 12527763
DOI: 10.1093/nar/gkg152
PMCID: PMC140516

Genes

DDB2
DDB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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