Article
Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.
Molecular and cellular biology - 1 Nov 1998
Yamabe Y, Shimamoto A, Goto M, Yokota J, Sugawara M, Furuichi Y
Abstract excerpt
The regulation of Werner's syndrome gene (WRN) expression was studied by characterizing the cis-regulatory elements in the promoter region and the trans-activating factors that bind to them. First, we defined the transcription initiation sites and the sequence of the 5' upstream region (2.8 kb) o...
Topics
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA Helicases
- DNA-Binding Proteins
- Down-Regulation
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- RNA, Messenger
- Retinoblastoma Protein
- Sequence Analysis, DNA
- Sp1 Transcription Factor
- Tumor Suppressor Protein p53