Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

Molecular and cellular biology - 1 Nov 1998

Yamabe Y, Shimamoto A, Goto M, Yokota J, Sugawara M, Furuichi Y

Abstract excerpt

The regulation of Werner's syndrome gene (WRN) expression was studied by characterizing the cis-regulatory elements in the promoter region and the trans-activating factors that bind to them. First, we defined the transcription initiation sites and the sequence of the 5' upstream region (2.8 kb) of WRN that contains a number of cis-regulatory elements, including 7 Sp1, 9 retinoblastoma control element (RCE), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 9774636
DOI: 10.1128/MCB.18.11.6191
PMCID: PMC109206

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.PMID 9774636Read ↗

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.Semantic proximity Read ↗

The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activitySemantic proximity Read ↗

Physical and Functional Interaction between p53 and the Werner's Syndrome ProteinSemantic proximity Read ↗

p53 Modulates RPA-Dependent and RPA-Independent WRN Helicase ActivitySemantic proximity Read ↗

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responsesSemantic proximity Read ↗

Werner syndrome protein contains three structure-specific DNA binding domains.Semantic proximity Read ↗

The Werner syndrome protein is involved in RNA polymerase II transcription.Semantic proximity Read ↗

Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by PhosphorylationSemantic proximity Read ↗

Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damages.Semantic proximity Read ↗

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choiceSemantic proximity Read ↗

Sequence-specific DNA Binding Activity of RNA Helicase A to the p16 PromoterSemantic proximity Read ↗

The transcriptional response to distinct growth factors is impaired in Werner syndrome cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.