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Article

Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum group E strains.

Oncogene - 25 Oct 2001

Itoh T, Nichols A, Linn S

Abstract excerpt

A damage-specific DNA binding protein (DDB) activity is absent from a subset (DDB(-)) of cells from individuals initially classified as group E of xeroderma pigmentosum (XP), a hereditary, photosensitive disease with a high incidence of skin malignancies. In these cases, mutations have been identified in the DDB2 gene (DDB2(-)) that codes for the small subunit, p48, of the DDB heterodimer. In four DDB2(-...

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Source

Identifiers

PMID: 11704828
DOI: 10.1038/sj.onc.1204909

Genes

DDB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum group E strains.PMID 11704828Read ↗

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.Semantic proximity Read ↗

Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.Semantic proximity Read ↗

Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53.Semantic proximity Read ↗

Xeroderma pigmentosum group E and DDB2, a smaller subunit of damage-specific DNA binding protein: proposed classification of xeroderma pigmentosum, Cockayne syndrome, and ultraviolet-sensitive syndrome.Semantic proximity Read ↗

Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype.Semantic proximity Read ↗

DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogenSemantic proximity Read ↗

Novel mutation identified in the DDB2 gene in patients with xeroderma pigmentosum group-E.Semantic proximity Read ↗

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.Semantic proximity Read ↗

Nucleotide excision repair genes involved in xeroderma pigmentosum.Semantic proximity Read ↗

Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repairSemantic proximity Read ↗

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.Semantic proximity Read ↗

DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision RepairSemantic proximity Read ↗

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