Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional Regulation of the TFIIH Transcription Repair Components XPB and XPD by the Hepatitis B Virus x Protein in Liver Cells and Transgenic Liver Tissue

1 Apr 2001

Abstract excerpt

Human hepatitis B virus is a risk factor for the development of hepatocellular carcinoma. The hepatitis B virus x protein (HBx) has been shown to inactivate the p53 tumor suppressor protein and impair DNA repair, cell cycle, and apoptosis mechanisms. Herein we report that HBx represses two components of the transcription-repair factor TFIIH, XPB (p89), and XPD (p80), both in p53-proficient and p53-deficient liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Hepatitis B Virus Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11278765
DOI: 10.1074/jbc.m010852200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Regulation of the TFIIH Transcription Repair Components XPB and XPD by the Hepatitis B Virus x Protein in Liver Cells and Transgenic Liver TissuePMID 11278765Read ↗

Hepatitis B virus X protein inhibits nucleotide excision repairSemantic proximity Read ↗

Hepatitis B virus X protein interferes with cellular DNA repair.Semantic proximity Read ↗

Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway.Semantic proximity Read ↗

Transcriptional repression of the human p53 gene by hepatitis B viral X proteinSemantic proximity Read ↗

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.Semantic proximity Read ↗

Hepatitis B virus X gene and hepatocarcinogenesis.Semantic proximity Read ↗

Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cellsSemantic proximity Read ↗

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants.Semantic proximity Read ↗

Hepatitis B Virus X Protein: Structure, Function and BiologySemantic proximity Read ↗

p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitroSemantic proximity Read ↗

Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.Semantic proximity Read ↗

Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.