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Article

STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation.

Journal of pregnancy - 1 Jan 2011

van Dijk Marie, Oudejans Cees B M

Abstract excerpt

Currently, only two preeclampsia susceptibility genes (ACVR2A, STOX1) have been identified within confirmed regions with significant genome-wide linkage, although many genetic screens in multiple populations have been performed. In this paper, we focus on the STOX1 gene. The epigenetic status of this gene is discussed explaining the maternal transmission of the STOX1 susceptibility allele observed in preeclamptic...

Topics

Activin Receptors, Type II
Alleles
Carrier Proteins
Epigenesis, Genetic
Female
Fetal Growth Retardation
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Models, Genetic
Pre-Eclampsia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Trophoblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 21490791
DOI: 10.1155/2011/521826
PMCID: PMC3066643

Genes

STOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Related research

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STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation.PMID 21490791Read ↗

Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia.Semantic proximity Read ↗

Targeting STOX1 in the therapy of preeclampsia.Semantic proximity Read ↗

Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 IsoformsSemantic proximity Read ↗

STOX1 promotor region -922 T > C polymorphism is associated with Early-Onset preeclampsia.Semantic proximity Read ↗

Differential methylation of STOX1 in human placenta.Semantic proximity Read ↗

STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defectsSemantic proximity Read ↗

STOX1 Overexpression in Choriocarcinoma Cells Mimics Transcriptional Alterations Observed in Preeclamptic PlacentasSemantic proximity Read ↗

Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.Semantic proximity Read ↗

Association of <em>STOX1</em> Maternal and Fetal Polymorphisms with Hypertensive Disorders of Pregnancy: Preliminary Evidence for a Parent-of-Origin Effect and Maternal-Fetal Genotypic InteractionSemantic proximity Read ↗

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.Semantic proximity Read ↗

Genetic aspects of preeclampsia.Semantic proximity Read ↗

STOX1 is not imprinted and is not likely to be involved in preeclampsiaSemantic proximity Read ↗

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