Article
Specificity protein-1 and -3 trans-activate the ovine placental lactogen gene promoter.
Molecular and cellular endocrinology - 13 Aug 2009
Jeckel K M, Limesand S W, Anthony R V
Abstract excerpt
The proximal promoter (-383/+16) of the ovine placental lactogen (oPL) gene provides trophoblast-specific expression in vitro. Footprint 6 (FP6; -319/-349) lies within this region, and transfection of two-base pair mutations across FP6 into BeWo cells identified potential binding sites for CCAAT-enhancer binding protein (CEBP) and specificity proteins (Sp). Transfection of CEBP dominant negative or...
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