Article
Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription.
Gene - 2 Jan 2003
Bertinato Jesse, Tomlinson Julianna J, Schild-Poulter Caroline, Haché Robert J G
Abstract excerpt
Ku antigen is an abundant nuclear protein with multiple functions that depend mainly on Ku's prolific and highly verstatile interactions with DNA. We have shown previously that the direct binding of Ku in vitro to negative regulatory element 1 (NRE1), a transcriptional regulatory element in the long terminal repeat of mouse mammary tumour virus, correlates with the regulation of viral transcription by Ku. In this...
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