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Functional analysis of promoter variants in KU70 and their role in cancer susceptibility.

Genes, chromosomes & cancer - 1 Nov 2012

Ouimet Manon, Cassart Pauline, Larivière Mathieu, Kritikou Ekaterini A, Simard Jacques, Sinnett Daniel

Abstract excerpt

KU70 is involved in the DNA double-strand break repair pathway, which plays a critical role in maintaining genomic stability and preventing cancer. Genetic variation within the KU70 gene has been shown to be associated with increased risk of several types of cancers including breast cancer. Here, we used gene reporter and gel shift assays combined with site-directed mutagenesis to characterize genetic variation...

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PMID: 22833453
DOI: 10.1002/gcc.21983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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