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Article

Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen.

1 Jun 1992

Abstract excerpt

The Ku antigen is a heterodimer consisting of 70- and 80-kD protein subunits that binds to termini of double-stranded DNA. DNA binding appears to be mediated partly by the 70-kD (p70) subunit, but the precise mechanism of its association with DNA is unclear. High-titer autoantibodies in sera from certain patients with systemic lupus erythematosus recognize at least eight distinct epitopes of Ku, and inhibit DNA...

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Identifiers

PMID: 1375268
DOI: 10.1084/jem.175.6.1677

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Related research

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Research trail→

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Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen.PMID 1375268Read ↗

A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen.Semantic proximity Read ↗

Construction of SV40 deletion mutants and delimitation of the binding domain for heat shock protein to the amino terminus of large T-antigen.Semantic proximity Read ↗

Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.Semantic proximity Read ↗

Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity.Semantic proximity Read ↗

Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions.Semantic proximity Read ↗

Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability.Semantic proximity Read ↗

HSP70 Binding Sites in the Tumor Suppressor Protein p53Semantic proximity Read ↗

Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism.Semantic proximity Read ↗

A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae.Semantic proximity Read ↗

Specific stimulation of human apurinic/apyrimidinic endonuclease by heat shock protein 70.Semantic proximity Read ↗

Characterization of human anti-heat shock protein 60 monoclonal autoantibody Fab fragments in atherosclerosis: genetic and functional analysis.Semantic proximity Read ↗

Human normal peripheral blood B-lymphocytes are deficient in DNA-dependent protein kinase activity due to the expression of a variant form of the Ku86 protein.Semantic proximity Read ↗

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