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Pharmacogenetics in Cancer Treatment

13 Jan 2003

Abstract excerpt

Interindividual variability in the efficacy and toxicity of drug therapy is associated with polymorphisms in genes encoding drug-metabolizing enzymes, transporters, or drug targets. Pharmacogenetics aims to identify individuals predisposed to high risk of toxicity from conventional doses of cancer chemotherapeutic agents. We review the role of genetic polymorphisms in UGT1A1 and TPMT, as well as mutations in DPD,...

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PMID: 12525681
DOI: 10.1146/annurev.med.54.101601.152352

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