Article
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.
Gastroenterology - 1 Sept 2003
Hirota Seiichi, Ohashi Akiko, Nishida Toshirou, Isozaki Koji, Kinoshita Kazuo, Shinomura Yasuhisa, Kitamura Yukihiko
Abstract excerpt
BACKGROUND & AIMS: Most gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of c-kit receptor tyrosine kinase (KIT) gene, but some GISTs do not. We investigated the cause of GISTs without KIT mutations. Because GISTs apparently expressed platelet-derived growth factor receptor (PDGFR) alpha, we examined whether GISTs without KIT mutations had a mutation of PDGFR alpha. METHODS: Whole coding...
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