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Article

Melanopsin gene polymorphism I394T is associated with pupillary light responses in a dose-dependent manner.

PloS one - 1 Jan 2013

Higuchi Shigekazu, Hida Akiko, Tsujimura Sei-ichi, Mishima Kazuo, Yasukouchi Akira, Lee Sang-il, Kinjyo Youhei, Miyahira Manabu

Abstract excerpt

BACKGROUND: Melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) play an important role in non-image forming responses to light, such as circadian photoentrainment, light-induced melatonin suppression, and pupillary light response. Although it is known that there are some single nucleotide polymorphisms (SNPs) in the melanopsin (OPN4) gene in humans, the associations of the SNPs with...

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Identifiers

PMID: 23555953
DOI: 10.1371/journal.pone.0060310
PMCID: PMC3610661

Genes

OPN4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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